diff --git a/CHANGELOG.md b/CHANGELOG.md
index fbd9e353..a96f0c83 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ Note: In this file, do not use the hard wrap in the middle of a sentence for com
 
 ## [Unreleased]
 
+- Update `wasmtime@latest` to 49.0.1.
+
 - Update `uv@latest` to 0.12.19.
 
 - Update `mise@latest` to 2026.9.13.
diff --git a/manifests/wasmtime.json b/manifests/wasmtime.json
index 00e43e5f..78aef751 100644
--- a/manifests/wasmtime.json
+++ b/manifests/wasmtime.json
@@ -35,13 +35,47 @@
     }
   },
   "latest": {
-    "version": "49.0.0"
+    "version": "49.0.1"
   },
   "49": {
-    "version": "49.0.0"
+    "version": "49.0.1"
   },
   "49.0": {
-    "version": "49.0.0"
+    "version": "49.0.1"
+  },
+  "49.0.1": {
+    "x86_64_linux_gnu": {
+      "etag": "0x8DF1A711F16520E",
+      "hash": "c71f7e0d30a92e418f0d17db7c6d8f6664c1ad764340a1278678f4209deab534"
+    },
+    "x86_64_macos": {
+      "etag": "0x8DF1A7120B263DE",
+      "hash": "56355136c4eaba17ef50b0e35e9774e25950333ba007c2a29c45d0906600e827"
+    },
+    "x86_64_windows": {
+      "etag": "0x8DF1A71227E6780",
+      "hash": "db0dd3dd77696fa189b08e256a50ddbe46d10a4d1e6c862d8d268ad0abc8c2c1"
+    },
+    "aarch64_linux_gnu": {
+      "etag": "0x8DF1A711AB93F64",
+      "hash": "7607529c40fed69c0f5d2a6fafa8c560b9e3c18ded31d8f1b13098afe49b7480"
+    },
+    "aarch64_macos": {
+      "etag": "0x8DF1A711AE2FA07",
+      "hash": "93dde14d4efb20046e5af75517ac6a7f2246f6c2370fecff8f68839d4a9028f7"
+    },
+    "aarch64_windows": {
+      "etag": "0x8DF1A711BB8EC34",
+      "hash": "98c4b6efc086198df195564573904ef0b0bcd435ab15a5469094c953b4b981bc"
+    },
+    "riscv64_linux_gnu": {
+      "etag": "0x8DF1A711D39E635",
+      "hash": "0b4e7a3ebf4ef0df17df0a37f49c6fc63a686ae4cd124cca9543e600b5a1db3d"
+    },
+    "s390x_linux_gnu": {
+      "etag": "0x8DF1A711DF76D81",
+      "hash": "7393615a48231c12a269b53ce1d3bac0fd34a3647cefa2b8570fdf90576d9082"
+    }
   },
   "49.0.0": {
     "x86_64_linux_gnu": {