diff --git a/CHANGELOG.md b/CHANGELOG.md
index a75a0708..f91dc28f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ Note: In this file, do not use the hard wrap in the middle of a sentence for com
 
 ## [Unreleased]
 
+- Update `wasmtime@latest` to 45.0.0.
+
 - Update `wasm-tools@latest` to 1.250.0.
 
 - Update `tombi@latest` to 0.11.6.
diff --git a/manifests/wasmtime.json b/manifests/wasmtime.json
index c17caace..98f98207 100644
--- a/manifests/wasmtime.json
+++ b/manifests/wasmtime.json
@@ -35,7 +35,13 @@
     }
   },
   "latest": {
-    "version": "44.0.1"
+    "version": "45.0.0"
+  },
+  "45": {
+    "version": "45.0.0"
+  },
+  "45.0": {
+    "version": "45.0.0"
   },
   "45.0.0": {
     "x86_64_linux_gnu": {