diff --git a/CHANGELOG.md b/CHANGELOG.md
index 10f83f23..26a0b004 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ Note: In this file, do not use the hard wrap in the middle of a sentence for com
 
 ## [Unreleased]
 
+- Update `wasmtime@latest` to 49.0.3.
+
 - Update `wasm-tools@latest` to 1.262.0.
 
 - Update `uv@latest` to 0.13.1.
diff --git a/manifests/wasmtime.json b/manifests/wasmtime.json
index cf3b7010..427341a7 100644
--- a/manifests/wasmtime.json
+++ b/manifests/wasmtime.json
@@ -35,13 +35,47 @@
     }
   },
   "latest": {
-    "version": "49.0.2"
+    "version": "49.0.3"
   },
   "49": {
-    "version": "49.0.2"
+    "version": "49.0.3"
   },
   "49.0": {
-    "version": "49.0.2"
+    "version": "49.0.3"
+  },
+  "49.0.3": {
+    "x86_64_linux_gnu": {
+      "etag": "0x8DF2A1706B4232E",
+      "hash": "4001225413f208345b980525f31c4080e1873808b38d0ddc7918497340667fbb"
+    },
+    "x86_64_macos": {
+      "etag": "0x8DF2A1707318CA2",
+      "hash": "bc131e20ed9cb34083fca1a203b38ec9d9e611e96596a10ab0cc9223cb06cd88"
+    },
+    "x86_64_windows": {
+      "etag": "0x8DF2A1708678F52",
+      "hash": "bee8f02158458a5f360412b232543d4fea379b71b94380b806e7980050596c18"
+    },
+    "aarch64_linux_gnu": {
+      "etag": "0x8DF2A17033C1B66",
+      "hash": "880fcb026da88ad7fc1713d572b0d03d139758b7da96cd3cb8c9cbf847a521df"
+    },
+    "aarch64_macos": {
+      "etag": "0x8DF2A1703CF2A69",
+      "hash": "d7708ba1cc2da171db2c8273d8602f3e0684935dc7cab40148cdcca1da83c0f8"
+    },
+    "aarch64_windows": {
+      "etag": "0x8DF2A170437ED74",
+      "hash": "bb1ece3bf1660db13f4a10f87436a79542af29b3acd75c0ff54bd0ffbc8d5b62"
+    },
+    "riscv64_linux_gnu": {
+      "etag": "0x8DF2A170571F0CE",
+      "hash": "0170ce5dc35cbd32f14f24519b5cab69ccd83df4815675442aefd721c5df9239"
+    },
+    "s390x_linux_gnu": {
+      "etag": "0x8DF2A1705DA52FA",
+      "hash": "19542355610e41ea84d9211077f4a36d18704bc5704ded79111de4b38c056790"
+    }
   },
   "49.0.2": {
     "x86_64_linux_gnu": {